The fire broke out at building in the 1300 block of St. Louis Ave just after 10 a.m.
One business owner said he pulled up to see one of his friends running out of the building with a fire extinguisher. The motorcycle shop owner and his friend were able to get their bikes out of the building.
"We saw people running out of the building and they pushed a motorcycle out of it," Tyler Hill, who works across from the building, said. "They were getting all of their stuff out."
Fire investigators say the fire started on the second floor and then ran the length of the building to the top floor.
"It's residential here and there's at least one business here," KCFD Captain James Garrett said. "Everyone's displaced at this time. So we've to one, get the fire knocked down, and two, investigate where the fire started and what the damage is."
Firefighters say that there was one person trapped, but crews were able to rescue that person right as the fire broke out.
A man and his two dogs had to be treated with oxygen. After he was done being treated, the man told FOX 4's Megan Dillard that he had to leave his cat behind because she ran and hid.
So far, no injuries have been reported.