KANSAS CITY, Mo. — Kansas City, Missouri police are investigating following a deadly single-vehicle crash involving a semi-truck Wednesday afternoon.

The crash was reported just after 4 p.m. on the westbound Interstate 70 off ramp and Interstate 435 on ramp near the Truman Sports Complex.

Police say the driver of the semi had been westbound and took the exit to I-435 southbound. As the vehicle came into a sweeping right curve, the driver lost control and the semi went off the left side of the roadway and overturned.

The vehicle then became engulfed in flames.

The driver and a passenger in the vehicle died at the scene.

Police said emergency vehicles have the ramp closed and portions of I-435 southbound to I-70 eastbound are blocked as well.

The ramp is expected to be closed for several hours while crews off load the contents and investigate the crash.

The cause of the crash and fire remain under investigation.

The Kansas City Fire Department remains on scene with a Haz Mat crew. The trailer of the semi was loaded with containers of an epoxy which were not burned in the fire, according to police.

No other vehicles were involved in the incident.

This is a developing story. FOX4 will have more information coming up on FOX4 News at 5 & 6.